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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


ThreaDom (Threading-based Protein Domain Prediction) is a template-based algorithm for protein domain boundary prediction. Given a protein sequence, ThreaDom first threads the target through the PDB library to identify protein template that have similar structure fold. A domain conservation score (DCS) will be calculated for each residue which combines information from template domain structure, terminal and internal gaps and insertions. Finally, the domain boundary information is derived from the DCS profile distributions. ThreaDom is designed to predict both continuous and discontinuous domains.

Note: We recently developed three new servers for protein domain modeling:


ThreaDom online

Copy and paste your sequence here (<4,000 residues, in FASTA format):

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)



  • Click ThreaDom Dataset to download the dataset of training and testing proteins.
  • Click Prediction of CASP8 to download the domain prediction of CASP8 targets.
  • Click The source code package to download the source code of ThreaDom.
    References:
    Z Xue, D Xu, Y Wang, Y Zhang. ThreaDom: Extracting Protein Domain Boundary Information from Multiple Threading Alignments. Bioinformatics, 29: i247-i256 (2013) (Download the PDF file).

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