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Name | Thromboxane A2 receptor |
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Species | Homo sapiens (Human) |
Gene | TBXA2R |
Synonym | TP receptor TXA2-R prostanoid TP receptor |
Disease | Diabetic neuropathy Cardiovascular disorder Erectile dysfunction Perennial allergic rhinitis Peripheral vascular disease [ Show all ] |
Length | 343 |
Amino acid sequence | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ |
UniProt | P21731 |
Protein Data Bank | 6iiv, 6iiu |
GPCR-HGmod model | P21731 |
3D structure model | This structure is from PDB ID 6iiv. |
BioLiP | BL0436518, BL0436517, BL0436516, BL0436515, BL0436514, BL0436513 |
Therapeutic Target Database | T76198 |
ChEMBL | CHEMBL2069 |
IUPHAR | 346 |
DrugBank | BE0000759 |
Name | Ramatroban |
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Molecular formula | C21H21FN2O4S |
IUPAC name | 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid |
Molecular weight | 416.467 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | SR-01000946208 [3H]BAY u3405 AJ-45646 BAY u3405;BAY-u3405 C21H21FN2O4S [ Show all ] |
Inchi Key | LDXDSHIEDAPSSA-OAHLLOKOSA-N |
Inchi ID | InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1 |
PubChem CID | 123879 |
ChEMBL | CHEMBL361812 |
IUPHAR | 1910, 1911 |
BindingDB | 50161746 |
DrugBank | DB13036 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 8.4 nM | PMID15715457 | BindingDB,ChEMBL |
IC50 | 9.6 nM | PMID15715457 | BindingDB,ChEMBL |
IC50 | 14.0 nM | PMID19608418 | BindingDB,ChEMBL |
Inhibition | 98.0 % | PMID15745833 | ChEMBL |
Ki | 0.58 nM | PMID21106375 | ChEMBL |
Ki | 0.58 nM | PMID21106375 | BindingDB |
Ki | 4.5 nM | PMID15715457 | BindingDB,ChEMBL |
Ki | 10.0 nM | PMID1387312 | IUPHAR |
Ki | 18.0 nM | PMID15745833 | BindingDB,ChEMBL |
Ki | 53.0 nM | PMID21106375 | BindingDB |
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