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Name | Orexin receptor type 2 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Hcrtr2 |
Synonym | hypocretin receptor 2 Hypocretin receptor type 2 hypocretin (orexin) receptor 2 orexin receptor type 2 Ox-2-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV |
UniProt | P56719 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1275216 |
IUPHAR | 322 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
2898 | DORA-22 | C23H22F2N4O2 | 424.452 | 7 / 0 | 3.6 | Yes |
18520 | SCHEMBL1717163 | C21H22FN3O2 | 367.424 | 4 / 1 | 3.7 | Yes |
40737 | Orexin receptor antagonist 10 | C19H18N6O2S | 394.453 | 7 / 0 | 3.0 | Yes |
56024 | Orexin receptor antagonist 31 | C21H19N5O2S | 405.476 | 7 / 0 | 3.0 | Yes |
59062 | Orexin receptor antagonist 17 | C21H21N7O3 | 419.445 | 8 / 0 | 2.6 | Yes |
70133 | Orexin receptor antagonist 34 | C23H20FN5O2 | 417.444 | 7 / 0 | 3.1 | Yes |
72668 | Orexin receptor antagonist 3 | C22H21N5O3 | 403.442 | 7 / 0 | 3.3 | Yes |
537847 | CHEMBL3973097 | C21H17F2N5O2 | 409.397 | 7 / 1 | 3.3 | Yes |
83216 | Orexin receptor antagonist 1 | C21H20N6O2 | 388.431 | 6 / 0 | 3.0 | Yes |
89454 | SCHEMBL1716434 | C24H25FN4O2 | 420.488 | 6 / 0 | 3.5 | Yes |
93146 | Orexin receptor antagonist 6 | C21H19FN6O2 | 406.421 | 7 / 0 | 3.1 | Yes |
474553 | CHEMBL3586442 | C21H22ClN7O | 423.905 | 6 / 0 | 3.3 | Yes |
102497 | SCHEMBL1717157 | C22H22FN5O4 | 439.447 | 8 / 1 | 3.1 | Yes |
102518 | Orexin receptor antagonist 4 | C22H22N6O2 | 402.458 | 6 / 0 | 3.4 | Yes |
102734 | SCHEMBL1716836 | C21H22ClN5O2 | 411.89 | 5 / 0 | 4.1 | Yes |
103191 | SCHEMBL1718116 | C21H22FN5O2 | 395.438 | 6 / 0 | 3.6 | Yes |
110093 | Orexin receptor antagonist 14 | C19H18N6O2S | 394.453 | 7 / 0 | 3.0 | Yes |
549248 | CHEMBL3955752 | C22H18F2N4O2 | 408.409 | 6 / 0 | 4.4 | Yes |
125058 | Orexin receptor antagonist 9 | C22H22N6O2 | 402.458 | 6 / 0 | 3.4 | Yes |
125315 | SCHEMBL1716942 | C25H26FN3O2 | 419.5 | 5 / 0 | 4.5 | Yes |
553922 | ACT 335827 | C31H38N2O5 | 518.654 | 6 / 1 | 5.5 | No |
127828 | SCHEMBL1717515 | C23H25FN4O2 | 408.477 | 5 / 1 | 3.9 | Yes |
479693 | CHEMBL3586434 | C21H22FN7O | 407.453 | 7 / 0 | 2.8 | Yes |
481287 | CHEMBL3586441 | C22H25N7O2 | 419.489 | 7 / 0 | 2.6 | Yes |
163667 | SCHEMBL1716852 | C22H23FN4O2 | 394.45 | 5 / 0 | 3.6 | Yes |
170685 | EMPA | C23H26N4O4S | 454.545 | 7 / 0 | 2.5 | Yes |
170818 | Orexin receptor antagonist 35 | C23H20FN5O2 | 417.444 | 7 / 0 | 3.1 | Yes |
485679 | CHEMBL3586432 | C21H23N7O | 389.463 | 6 / 0 | 2.7 | Yes |
197641 | Orexin receptor antagonist 33 | C23H20FN5O2 | 417.444 | 7 / 0 | 3.1 | Yes |
487649 | CHEMBL3586440 | C22H25N7O | 403.49 | 6 / 0 | 3.0 | Yes |
487710 | CHEMBL3586426 | C23H24N4OS | 404.532 | 5 / 0 | 4.0 | Yes |
209252 | Orexin receptor antagonist 2 | C23H21N5O2 | 399.454 | 6 / 0 | 3.0 | Yes |
218366 | SCHEMBL1717126 | C24H23FN4O4 | 450.47 | 8 / 1 | 3.1 | Yes |
223441 | SCHEMBL1717503 | C23H23FN4O2 | 406.461 | 6 / 0 | 3.5 | Yes |
228865 | FILOREXANT | C24H25FN4O2 | 420.488 | 6 / 0 | 3.9 | Yes |
231294 | SCHEMBL1716701 | C24H25FN4O3 | 436.487 | 7 / 1 | 2.6 | Yes |
492077 | CHEMBL3586437 | C21H23N7O | 389.463 | 6 / 1 | 2.4 | Yes |
253161 | SCHEMBL1717179 | C23H22F2N4O2 | 424.452 | 7 / 0 | 3.6 | Yes |
258157 | Orexin receptor antagonist 36 | C23H20FN5O2 | 417.444 | 7 / 0 | 3.1 | Yes |
259186 | SCHEMBL1716476 | C21H21F2N5O2 | 413.429 | 7 / 0 | 3.7 | Yes |
272055 | Orexin receptor antagonist 20 | C22H24N4O3 | 392.459 | 6 / 0 | 2.8 | Yes |
273233 | Orexin receptor antagonist 5 | C22H22N6O2 | 402.458 | 6 / 0 | 3.4 | Yes |
277890 | SCHEMBL1717023 | C21H25FN2O3 | 372.44 | 5 / 0 | 3.9 | Yes |
291171 | SCHEMBL1716967 | C22H25N5O2 | 391.475 | 5 / 0 | 3.9 | Yes |
292348 | CHEMBL3655663 | C21H22FN5O2 | 395.438 | 6 / 0 | 3.5 | Yes |
500274 | CHEMBL3586433 | C21H22FN7O | 407.453 | 7 / 0 | 2.8 | Yes |
313882 | SCHEMBL1716975 | C22H24FN5O3 | 425.464 | 7 / 1 | 2.7 | Yes |
502512 | UNII-AIS8N3O50B | C21H22FN7O | 407.453 | 7 / 0 | 2.8 | Yes |
554860 | Seltorexant | C21H22FN7O | 407.453 | 7 / 0 | 2.8 | Yes |
321456 | SCHEMBL1717368 | C24H24FN3O2 | 405.473 | 5 / 0 | 4.5 | Yes |
324936 | SCHEMBL1716390 | C22H24FN5O2 | 409.465 | 6 / 0 | 3.9 | Yes |
331510 | Orexin receptor antagonist 22 | C21H19FN6O2 | 406.421 | 7 / 0 | 3.1 | Yes |
333699 | SCHEMBL1716517 | C26H27FN2O2 | 418.512 | 4 / 0 | 5.6 | No |
336909 | SCHEMBL1716725 | C23H24FN3O2S | 425.522 | 6 / 0 | 4.6 | Yes |
348500 | Orexin receptor antagonist 30 | C20H19N7O2 | 389.419 | 7 / 0 | 2.9 | Yes |
545487 | CHEMBL3394848 | C23H19F2N5O2 | 435.435 | 7 / 0 | 4.5 | Yes |
358336 | SCHEMBL1716924 | C21H22BrN5O2 | 456.344 | 5 / 0 | 4.2 | Yes |
362950 | Orexin receptor antagonist 15 | C21H19BrN6O2 | 467.327 | 6 / 0 | 3.7 | Yes |
456080 | MK-3697 | C23H21N5O3S | 447.513 | 8 / 1 | 2.5 | Yes |
370236 | Orexin receptor antagonist, 7 | C21H19ClN6O2 | 422.873 | 6 / 0 | 3.6 | Yes |
456696 | SCHEMBL9977884 | C21H20FN7O | 405.437 | 6 / 0 | 2.4 | Yes |
386821 | Orexin receptor antagonist 8 | C21H19FN6O2 | 406.421 | 7 / 0 | 3.1 | Yes |
396186 | Orexin receptor antagonist 32 | C21H19N5O2S | 405.476 | 7 / 0 | 2.7 | Yes |
533102 | CHEMBL3741194 | C25H26N2O5S | 466.552 | 7 / 0 | 5.1 | No |
430289 | SB-649868 | C26H24FN3O3S | 477.554 | 6 / 1 | 5.2 | No |
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