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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	triprolidine
Molecular formula	C19H22N2
IUPAC name	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Molecular weight	278.399
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.9
Synonyms	(E)-2-1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL-PYRIDINE Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1) 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine chloride Tox21_110919 550-70-9 (mono-hydrochloride) Tripolidina [INN-Spanish] Actidil Triprolidinum BIM-0025383.P001 CBEQULMOCCWAQT-WOJGMQOQSA-N D0E8CI GTPL1228 LS-1293 NCGC00024714-05 Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)- 2-[(E)-1-(p-tolyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridine trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene AB00053563-13 Triprolidine (INN) AKOS027460758 Venen (TN) BRD-K11742128-003-15-0 CHEBI:84116 DSSTox_CID_3718 HSDB 6316 Myidil (TN) NCGC00024714-08 Prestwick2_000262 2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine Spectrum5_001467 486T124 TRIPHED ACM486124 Triprolidine Monohydrochloride, Monohydrate BDBM50292411 C19H22N2 CORPHED DTXSID3023718 L000901 NCGC00024714-03 (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine Tox21_110919_1 6138-79-0 (mono-hydrochloride, mono-hydrate) Triprolidin Actidil (TN) Triprolidinum [INN-Latin] BPBio1_000116 CCG-12422 Histafed MolPort-003-182-178 NCGC00024714-06 NCGC00024714-11 2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine SBI-0025383.P004 2L8T9S52QM trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine AB00053563_14 Triprolidine HCL ALLERFED ZINC12503099 BSPBio_000104 DSSTox_GSID_23718 IDI1_000297 Myidyl Prestwick3_000262 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine T 6764 Tripolidina ACTAHIST Triprolidine [INN:BAN] BIDD:GT0569 CAS-486-12-4 D08648 EINECS 207-627-0 Lopac0_001130 NCGC00024714-04 (E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine 1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene AB00053563-02 Actifed UNII-2L8T9S52QM BRD-K11742128-003-05-1 CCRIS 7212 DB00427 HMS2089M21 MYFED NCGC00024714-07 NCI-C61450 2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine SCHEMBL4905 486-12-4 TRILITRON AC1NR02Y Triprolidine Monohydrochloride AN-45232 BSPBio_002255 CHEMBL855 DSSTox_RID_77161 KB-105517 NCGC00024714-02 [ Show all ]
Inchi Key	CBEQULMOCCWAQT-WOJGMQOQSA-N
Inchi ID	InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
PubChem CID	5282443
ChEMBL	CHEMBL855
IUPHAR	1228
BindingDB	50292411
DrugBank	DB00427
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
37806	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
37802	Histamine H1 receptor	P31389	HRH1	Cavia porcellus (Guinea pig)	488
37803	Histamine H1 receptor	P31390	Hrh1	Rattus norvegicus (Rat)	486
37804	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487
37805	Histamine H2 receptor	P47747	HRH2	Cavia porcellus (Guinea pig)	359

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