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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	ACRIVASTINE
Molecular formula	C22H24N2O2
IUPAC name	(E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid
Molecular weight	348.446
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.6
Synonyms	UNII-A20F9XAI7W (2E)-3-[6-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-2-propenoic acid (E,E)-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid AC1NR4LM Acrivastine, >=98% (HPLC) Benadryl allergy relief BW825C D0O4EU HY-B1510 PWACSDKDOHSSQD-IUTFFREVSA-N Semprex (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid 54338-EP2308562A2 Acrivastina AKOS005067182 BW 0270C CHEBI:83168 DSSTox_CID_2555 L917 SR-01000942220-1 (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid A20F9XAI7W Acrivastine (USAN/INN) BC224208 BW-825C CS-6454 DTXSID6022555 MolPort-005-942-272 ZINC3776633 (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid 2-Propenoic acid, 3-(6-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-2-pyridinyl)-, (E,E)- AC1Q5T9P Acrivastinum BG0518 C22H24N2O2 I14-8671 Q-200590 SMR004701250 (E)-3-[6-[(E)-1-(p-tolyl)-3-pyrrolidin-1-yl-prop-1-enyl]-2-pyridyl]prop-2-enoic acid 848A995 Acrivastina [Spanish] AN-15417 BW 825C DSSTox_GSID_22555 LS-178016 Tox21_113015 ( E,E )-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid (E)-6-((E)-3-(1-Pyrrolidinyl-1-p-tolylpropenyl)-2-pyridinacrylsaeure AC-912 Acrivastine [USAN:INN:BAN] BCP06189 BW270C D02760 E-(9CI) NCGC00182053-02 (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid 3-{6-[1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid Acrivastin Acrivastinum [Latin] BIDD:GT0209 CAS-87848-99-5 DB09488 KM2560 SCHEMBL4702 SR-01000942220 (E)-3-{6-[3-pyrrolidino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid 87848-99-5 AS-14623 BW A825C CHEMBL1224 DSSTox_RID_76625 MLS006010115 [ Show all ]
Inchi Key	PWACSDKDOHSSQD-IUTFFREVSA-N
Inchi ID	InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
PubChem CID	5284514
ChEMBL	CHEMBL1224
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB09488
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
270296	Histamine H1 receptor	P31389	HRH1	Cavia porcellus (Guinea pig)	488
270297	Histamine H1 receptor	P70174	Hrh1	Mus musculus (Mouse)	488
551254	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487

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